The role of retinal photoreceptors in the regulation of circadian rhythms and sleep in systemic disease
Summary:
The paper discusses the role of retinal photoreceptors in the regulation of circadian rhythms and sleep in systemic diseases, specifically focusing on diabetes and Parkinson's disease.
Categories
- Diabetes and metabolic syndrome: The paper discusses how retinal photoreceptor dysfunction in diabetes can cause desynchronization between ambient light inputs and the timing of the suprachiasmatic nucleus, resulting in abnormal circadian photoentrainment and poor sleep.
- Parkinson's disease: The paper explores how in Parkinson's disease, there is normal outer retinal function, however the intrinsic melanopsin-mediated PIPR for blue and green stimuli is significantly reduced, leading to sleep deficits.
- Sleep and insomnia: The paper discusses how retinal photoreceptor dysfunction can lead to poor sleep in both diabetes and Parkinson's disease.
- Cognitive function and memory: The paper indirectly discusses cognitive function and memory by exploring how circadian rhythms and sleep, which are crucial for cognitive function and memory, are affected in diabetes and Parkinson's disease.
- Eye health: The paper focuses on the role of retinal photoreceptors, a crucial part of eye health, in the regulation of circadian rhythms and sleep in systemic diseases.
Author(s)
S Dumpala
Publication Year:
2020
Number of Citations:
0
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