Molecular regulations of circadian rhythm and implications for physiology and diseases
Summary:
This paper reviews the molecular regulations of circadian rhythm and its implications for physiology and diseases, discussing the role of the biological clock in controlling physiological functions of almost all tissues and organs, and its implications in human pathologies such as cancer and inflammatory diseases.
Categories
- Cancer treatment and prevention: The paper discusses how disruption of circadian rhythm can affect physiological processes relevant to human diseases, including cancer, and how understanding this field can contribute to the establishment of a circadian precision medicine.
- Immune system function and health: The paper discusses how the biological clock plays a key role in controlling physiological functions of almost all tissues and organs, including the immune response.
- Hormone regulation: The paper discusses how the circadian clock regulates several intracellular signaling pathways, including hormone regulation.
- Phototherapy: The paper discusses how circadian rhythms can be challenged by environmental factors, including light/dark cycles, and how this can have implications for human pathologies.
- Lighting Design Considerations: The paper discusses how the daily light–dark cycle represents the primary external synchronizer of circadian rhythms, which is relevant to lighting design considerations.
Author(s)
F Fagiani, D Di Marino, A Romagnoli
Publication Year:
2022
Number of Citations:
96
Related Publications
Cancer treatment and prevention
- The end of night: searching for natural darkness in an age of artificial light
- Light during darkness and cancer: relationships in circadian photoreception and tumor biology
- Light pollution and cancer
- Phospholipase C families: Common themes and versatility in physiology and pathology
Immune system function and health
- The effect of light on critical illness
- Light at night disrupts biological clocks, calendars, and immune function
- New insights into the diurnal rhythmicity of gut microbiota and its crosstalk with host circadian rhythm
- A new perspective on Huntington's disease: how a neurological disorder influences the peripheral tissues
Hormone regulation
- Phototransduction by retinal ganglion cells that set the circadian clock
- The impact of light from computer monitors on melatonin levels in college students
- Circadian rhythms–from genes to physiology and disease
- Effects of artificial dawn and morning blue light on daytime cognitive performance, well-being, cortisol and melatonin levels
Phototherapy
- Phototransduction by retinal ganglion cells that set the circadian clock
- Strange vision: ganglion cells as circadian photoreceptors
- Function of human pluripotent stem cell-derived photoreceptor progenitors in blind mice
- Lux vs. wavelength in light treatment of Seasonal Affective Disorder
Lighting Design Considerations
- Color appearance models
- Melanopsin-positive intrinsically photosensitive retinal ganglion cells: from form to function
- Acute alerting effects of light: A systematic literature review
- Form and function of the M4 cell, an intrinsically photosensitive retinal ganglion cell type contributing to geniculocortical vision