Summary
This paper investigates the degeneration of intrinsically photosensitive retinal ganglion cells (ipRGCs) in mouse models of Huntington's disease, and how this contributes to the disruption of non-image-forming behaviors before motor impairment.
Categories
Dementia: The paper discusses the degeneration of ipRGCs in neurodegenerative diseases, including Alzheimer's disease.
Alzheimer's disease: The paper mentions that ipRGCs are affected in Alzheimer's disease, which is associated with impaired circadian rhythms.
Cognitive function and memory: The paper discusses how the degeneration of ipRGCs in Huntington's disease can lead to nonmotor symptoms such as impaired cognitive functions.
Aging: The paper discusses how ipRGCs are affected in aging, which is associated with impaired circadian rhythms.
Phototherapy: The paper discusses the role of light in the functioning of ipRGCs, which are photosensitive neurons in the retina.
Lighting Design Considerations: The paper's findings on the role of light in the functioning of ipRGCs could have implications for lighting design considerations in environments for individuals with neurodegenerative diseases.
Author(s)
MS Lin, PY Liao, HM Chen, CP Chang
Publication Year
2019
Number of Citations
23
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