Neurogenetic basis for circadian regulation of metabolism by the hypothalamus

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Summary

This paper discusses the neurogenetic basis for circadian regulation of metabolism by the hypothalamus, focusing on how circadian rhythms are driven by a transcription–translation feedback loop that separates anabolic and catabolic processes across the Earth's 24-h light–dark cycle.

Categories

Cognitive function and memory: The paper discusses how circadian rhythms and the central clock drive appetitive behavior and metabolic homeostasis, which are crucial for cognitive function and memory.

Sleep and insomnia: The paper discusses how hypothalamic neurons involved in regulation of sleep/wake and fast/feeding states interact with the central pacemaker neurons that perceive light and entrain a distributed clock network.

Hormone regulation: The paper discusses how the central clock and circadian rhythms regulate the release of hormones from the pituitary, such as adrenocorticotropic hormone that regulates release of cortisol, an important signal of entrainment for peripheral oscillators.

Diabetes and metabolic syndrome: The paper discusses how circadian rhythms and the central clock regulate metabolic homeostasis, which is crucial for the prevention and management of diabetes and metabolic syndrome.

Aging: The paper discusses how changes in some of the mechanisms involved in circadian rhythms, such as NAD+, have been implicated in the age-associated decline in circadian function.