Abstract

Summary

The paper discusses sleep and circadian rhythm dysfunction in animal models of Huntington’s disease, focusing on the relevance of these findings to humans with the disease and potential therapeutic interventions.
Categories

Categories

Dementia: The paper references 'sundowning', a behavioral symptom often seen in dementia patients, in relation to the abnormal patterns of activity observed in HD sheep.
Sleep and insomnia: The paper extensively discusses sleep disorders and circadian rhythm dysfunction in Huntington's disease, using various animal models to study these phenomena.
Cognitive function and memory: The paper mentions cognitive decline in relation to circadian dysfunction in Huntington's disease mice models.
Aging: The paper discusses the progression of Huntington's disease symptoms with age in various animal models.
Hormone regulation: The paper discusses the disruption of hormone rhythms, such as melatonin, in Huntington's disease animal models.
Phototherapy: The paper discusses the abnormal response of R6/2 mice to photic entrainment, a form of light therapy.
Authors

Author(s)

AJ Morton
Publication Date

Publication Year

2023
Citations

Number of Citations

1
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