Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice
Summary:
The paper investigates the impact of perinatal fentanyl exposure on gene expression in the brains of juvenile mice, revealing significant alterations in reward and sensory brain regions that may underlie structural, functional, and behavioral changes.
Categories
- Substance Abuse and Dependence: The paper studies the effects of perinatal exposure to the synthetic opioid fentanyl, a substance often misused and associated with addiction.
- Reproductive health: The paper discusses the impact of fentanyl exposure during pregnancy, highlighting potential risks for neonatal outcomes and long-term behavioral disruptions.
- Cognitive function and memory: The paper explores how perinatal fentanyl exposure can affect gene expression in brain regions associated with reward and sensory processing, potentially impacting cognitive function.
- Psychiatric Disorders: The paper suggests that perinatal fentanyl exposure can lead to enhanced negative affect and behavioral disruptions during adolescence, which may be relevant to various psychiatric disorders.
Author(s)
J Olusakin, G Kumar, M Basu, CA Calarco
Publication Year:
2023
Number of Citations:
2
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