Summary
This research reveals that mu-opioid receptors (MORs) on ipRGCs play a role in regulating sleep/wake behavior and circadian entrainment, suggesting opioid bioavailability in the retina can influence circadian light responses. For lighting and healthcare applications, this implies that opioid medications may interfere with circadian photoentrainment, potentially affecting sleep quality and circadian health in patients receiving opioid therapy.
Key Findings
- MORs expressed by ipRGCs modulate the light-mediated signaling that drives circadian entrainment and sleep/wake behavior.
- Endogenous MOR activation in ipRGCs contributes to morphine-related effects on circadian and sleep responses.
- The abstract is highly truncated, limiting extraction of specific quantitative findings.
Categories
Sleep & Circadian Health: The paper investigates how opioid receptor activation in ipRGCs modulates sleep/wake behavior and circadian light responses.
The Science of Light: The study examines the role of mu-opioid receptors (MORs) expressed by intrinsically photosensitive retinal ganglion cells (ipRGCs) in modulating non-visual light signaling.
Author(s)
CT Berezin
Publication Year
2023
Related Publications
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The Science of Light
- Phototransduction by retinal ganglion cells that set the circadian clock
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- The mammalian circadian timing system: organization and coordination of central and peripheral clocks
- Diminished pupillary light reflex at high irradiances in melanopsin-knockout mice
- Melanopsin is required for non-image-forming photic responses in blind mice